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Advanced Knee Care

Knee Surgeon and Specialist Stefan D. Tarlow, M.D.

  • SURGICAL TREATMENTS
    • Robotic Mako Total Knee Replacement
    • Makoplasty Robotic Partial Knee Surgery
    • Robotic Cementless (Press Fit) Total Knee Replacement
    • ACL Reconstruction
    • Knee Arthroscopy
    • Knee Cartilage Repair Restoration Surgery
    • Subchondroplasty
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    • My Knee Cap Hurts
    • Hyalofast Cartilage Restoration Surgery
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PRP Knee Injections: A Natural Approach to Relieve Joint Pain and Promote Healing

July 19, 2023 By Stefan D. Tarlow MD

happy old couple

In this blog post, we will explore the use of Platelet-Rich Plasma (PRP) injections for knee pain and injuries. We will explore the science behind PRP knee injections, their potential benefits, the procedure, and what patients can expect during treatment. We will provide insight into the recovery process and answer questions.

Understanding PRP and its Role in Knee Injuries

PRP in test tube

Platelet-Rich Plasma (PRP) is a regenerative medicine treatment that utilizes the healing properties of your blood. PRP for the knee is a non-surgical procedure that can be performed in-office, offering a natural approach to alleviate joint pain and promote healing. The process involves a nurse collecting a tube of your blood. The blood is spun twice, which allows us to concentrate on the healing elements. The PRP is placed in a sterile syringe. Dr. Tarlow then injects the PRP directly into your knee joint capsule, stimulating a biological, regenerative repair process.

The Procedure and Preparation

medical staff preparing platelet rich plasma

To obtain PRP, a small amount of your blood is drawn by a nurse from your arm. The drawn blood is then processed in the office using a specialized technique. Emcyte PurePRP, a trusted and high-quality preparation, is used to produce the PRP. The PRP is then carefully injected into your knee joint. The procedure typically takes about one hour, making it a convenient option for patients seeking effective pain relief and improved joint function.

PRP for Chondral Defects

PRP for chondral defects

Knee chondral defects are conditions where the joint surface develops a surface imperfection. These chondral defects are known to generate knee symptoms. The knee has a limited ability to repair itself and lacks biological activity. This can lead to chronic knee pain and swelling. However, PRP has shown promising outcomes in treating mild to moderate defects, particularly in knees that are otherwise healthy. PRP contains a high concentration of growth factors from your blood, which can aid in healing and stimulate the growth of cells or the metabolism of the matrix in the articular chondrocytes. By utilizing the regenerative properties of PRP, patients with chondral defects may find relief from pain and experience improved knee function. This relief usually continues for a year.

PRP for Osteoarthritis (OA) Knees

knee doctor injecting PRP

Osteoarthritis is a degenerative joint condition that alters normal joint metabolism, leading to increased cell breakdown and decreased repair. PRP can be an effective treatment option for mild to moderate knee osteoarthritis. This helps alleviate pain and swelling associated with knee osteoarthritis. This relief usually continues for a year.

How PRP Works in Knee Osteoarthritis and Chondral Defects

nurse tending on old mans knees

PRP works in different ways to improve the balance and healing of the joints. When PRP is injected, it releases growth factors from platelet alpha-granules, including hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and transforming growth factor-b (TGF-b). These growth factors play a crucial role in stimulating the healing processes within the joint. PRP also affects the cells lining the knee called synoviocytes. It increases the secretion of hyaluronic acid (HA), which helps maintain a healthy joint environment with balanced blood flow. Additionally, PRP reduces the presence of “bad proteins” like interleukin-1 (IL-1) and matrix metalloproteinases (MMPs) that contribute to joint inflammation. As a result, PRP helps suppress joint inflammation, alleviating pain, which is the most significant and debilitating symptom of knee osteoarthritis.

Ready to Schedule a Consultation?

If you seek a natural and practical approach to alleviate knee joint pain and promote healing, PRP knee injections may be the right choice. Dr. Tarlow at Advanced Knee Care specializes in PRP therapy can guide you through the process. To get started, complete our request form or contact our trained staff by phone or e-mail. We are here to address your questions and assist you throughout your treatment journey.

Filed Under: PRP

PRP for Knee Chondral Defects

May 5, 2018 By Stefan D. Tarlow MD

PRP for Chondral Defects): Partial Thickness Knee Lesions

PRP (platelet rich plasma) is an injection treatment performed in the office. PRP for the knee is a biologic regenerative medicine treatment that does not require a surgical procedure.  Knee chondral defects have a limited capacity for self repair due to the low biologic activity of chondrocytes and its lack of blood supply. Articular cartilage defects often fail to heal spontaneously and may result in progressive deterioration and eventually osteoarthritis.

PRP is used to treat the symptoms from partial thickness chondral defects of the knee. Platelet-rich plasma (PRP), with a rich source of autologous growth factors, can promote healing of partial thickness chondral defects in otherwise healthy knees.   PRP owes its therapeutic use to scientific evidence that growth factors released by the platelets possess multiple regenerative properties. Platelets are involved the complex process of tissue repair by the release of these growth factors. Studies have suggested that PRP stimulate either cell proliferation or matrix metabolism by articular chondrocytes

Symptoms of Knee Chondral Defect:

Patients with a knee chondral defect may have pain and swelling with activities, or a “noisy knee” .  The diagnosis is made with a 3T MRI.

PRP is an In Office Procedure:

PRP comes from your blood.  A nurse draws the needed amount of blood from your arm.  Your blood is processed in the office and the PRP that is produced is then injected into your knee.  The process takes 1 hour.  The preparation used at Advanced Knee Care is Emcyte PurePRP (https://www.emcyte.com/pureprp-sp/. For knee OA, leucocyte-poor PRP appears to be better than leucocyte-rich PRP.

How does it work in Chondral Defect knees?

In the knee, the release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year. Prolonged and sustained release of growth factors from platelets could possibly help in biological healing and anti inflammatory effects.

More specifically (and a bit technical):

PRP acts at various levels to alter and improve the joint homeostasis.

Within the knee: Platelet alpha-granules contain and release numerous growth factors, including hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and transforming growth factor-b (TGF-b) , which are good proteins in may promote healing.

The cells lining the knee, synoviocytes are influenced by increased hyaluronic acid (HA) secretion, creating a more favourable and balanced state of blood flow, and a decreased of “bad proteins” like interleukin-1 (IL-1) and  matrix metalloproteinases (MMPs).

The death of knee cartilage cells (chondrocytes) is probably diminished through a complex interaction of PRP in the knee joint as insulin-like growth factor 1 (IGF-1) in PRP may slow the expression of programmed cell death 5 (PDCD5). 

An overall suppression of the joint inflammation can explain the pain reduction effect, which is the most prominent and disabling symptom of knee OA.  PRP counteracted the inflammatory cascade by inhibiting these “bad proteins” with names like IL-1ß,TNF-α, COX-2 and MMP-2 gene expression.

Researchers have noticed increase in mRNA levels of cannabinoid receptors CB1 and CB2 (receptors involved in analgesic and anti-inflammatory effects) and this could explain the analgesic effect of PRP.

PRP is safe.

PRP is a fascinating biological possibility as a therapeutic approach for cartilage pathology.

The present state of knowledge holds promise for PRP in certain applications to promote healing of  Knee Chondral defects. Nevertheless, a lot of grey areas remain in our understanding of PRP and articular cartilage healing, and many more focused clinical and in vitro studies are required. 

PRP is definitely there to stay for knee cartilage therapy treatment in future.

Filed Under: platelet rich plasma, PRP

PRP for Knees – OA

April 27, 2018 By Stefan D. Tarlow MD

PRP for OA (osteoarthritis knees):

PRP (platelet rich plasma) is an injection treatment performed in the office. PRP for the knee is a biologic regenerative medicine treatment that does not require a surgical procedure.  This treatment is used to modify the symptoms of knee OA (osteoarthritis) by counteracting the natural process of Osteoarthritis which alters the normal joint metabolism resulting in increased cell breakdown and decreased cell repair.

PRP for partial thick chondral defects-see my post on this subject.PRP can  promote healing of partial thickness chondral defects in otherwise healthy knees.   Platelet-rich plasma (PRP), with a rich source of autologous growth factors, can promote healing ofpartial thickness chondral defects in otherwise healthy knees.

PRP is an In Office Procedure:

PRP comes from your blood.  A nurse draws the needed amount of blood from your arm.  Your blood is processed in the office and the PRP that is produced is then injected into your knee.  The process takes 1 hour.  The preparation used at Advanced Knee Care is Emcyte PurePRP (https://www.emcyte.com/pureprp-sp/). For knee OA, leucocyte-poor PRP appears to be better than leucocyte-rich PRP.

How does it work in OA knees?

In the knee, the release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year. Prolonged and sustained release of growth factors from platelets could possibly help in biological healing and anti inflammatory effects.

More specifically (and a bit technical):

PRP acts at various levels to alter and improve the joint homeostasis.

Within the knee: Platelet alpha-granules contain and release numerous growth factors, including hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and transforming growth factor-b (TGF-b) , which are good proteins in may promote healing.

The cells lining the knee, synoviocytes are influenced by increased hyaluronic acid (HA) secretion, creating a more favourable and balanced state of blood flow, and a decreased of “bad proteins” like interleukin-1 (IL-1) and  matrix metalloproteinases (MMPs).

The death of knee cartilage cells (chondrocytes) is probably diminished through a complex interaction of PRP in the knee joint as insulin-like growth factor 1 (IGF-1) in PRP may slow the expression of programmed cell death 5 (PDCD5).

An overall suppression of the joint inflammation can explain the pain reduction effect, which is the most prominent and disabling symptom of knee OA.  PRP counteracted the inflammatory cascade by inhibiting these “bad proteins” with names like IL-1ß,TNF-α, COX-2 and MMP-2 gene expression.

Lee et al. [15] noticed increase in mRNA levels of cannabinoid receptors CB1 and CB2 (receptors involved in analgesic and anti-inflammatory effects) and this could explain the analgesic effect of PRP.

PRP is safe.

The present state of knowledge holds promise for PRP of certain specifications for pain management in the early OA knee. PRP has consistently been shown by various clinical studies to be superior to HA. Nevertheless, a lot of grey areas remain in our understanding of PRP and OA, and many more focused clinical and in vitro studies are required. PRP is definitely there to stay for OA therapy use in future.

Filed Under: platelet rich plasma, PRP

Our Recent Posts

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  • A Comprehensive Guide to Understanding Patello-Femoral Replacement Surgery
  • ACL Reconstruction: What to Expect Before, During, and After Surgery
  • PRP Knee Injections: A Natural Approach to Relieve Joint Pain and Promote Healing

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Scottsdale Knee Specialist & Surgeon – Stefan D. Tarlow M.D

Stefan D. Tarlow, MD, is Arizona’s premier “knees only” orthopedic surgeon.

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ARTICLES

The Patient’s Guide to Medicare and Robotic Knee Replacement

Why Out-of-Network Doctors are a Preferred Choice for Robotic Knee Replacement

A Comprehensive Guide to Understanding Patello-Femoral Replacement Surgery

ACL Reconstruction: What to Expect Before, During, and After Surgery

PRP Knee Injections: A Natural Approach to Relieve Joint Pain and Promote Healing

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  • SURGICAL TREATMENTS
    ▼
    • Robotic Mako Total Knee Replacement
    • Makoplasty Robotic Partial Knee Surgery
    • Robotic Cementless (Press Fit) Total Knee Replacement
    • ACL Reconstruction
    • Knee Arthroscopy
    • Knee Cartilage Repair Restoration Surgery
    • Subchondroplasty
    • Knee Arthritis Treatment Options
    • Patello Femoral (Knee Cap) Replacement Surgery
    • My Knee Cap Hurts
    • Hyalofast Cartilage Restoration Surgery
  • SPORTS INJURIES
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    • Basketball Knee Injuries
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